A 2025 randomized, double-blind, placebo-controlled trial explored whether a combination of Polypodium leucotomos, Red Orange extract, and vitamins could help strengthen the skin’s natural defenses against UVB exposure.

After eight weeks, participants showed a 23.8% increase in UV tolerance and a 46.2% reduction in UVB-induced redness, without significantly affecting tanning.

In Episode 136 of the Orange Pill Podcast, we explore the emerging science of oral photoprotection and why the future of sun protection may involve supporting the skin from both the outside and the inside.