Creatine may be famous for building muscle, but its next frontier could be the brain.

A 2024 systematic review and meta-analysis of 16 randomized controlled trials found that creatine supplementation was associated with improvements in memory, with additional promising findings around attention and processing speed.

In Episode 138 of the Orange Pill Podcast, we explore how creatine helps fuel the brain’s enormous energy demands, why women and younger adults showed particularly interesting results in some analyses, and what the evidence really says about creatine as a tool for cognitive performance.

Turns out, creatine may have a lot more to offer beyond the bench press.