GLP-1 receptor agonists have transformed the conversation around obesity and metabolic health. But as their use continues to grow, researchers and clinicians are beginning to pay closer attention to the nutritional consequences that can accompany significant appetite suppression, rapid weight loss, and persistent gastrointestinal side effects.

In this episode of The Orange Pill Podcast, we explore the emerging concern around thiamine (vitamin B1) deficiency in people using GLP-1 receptor agonists.

Thiamine stores in the body are limited, and prolonged reductions in food intake or recurrent vomiting can potentially lead to deficiency faster than many realize. In severe cases, this can result in neurological complications such as Wernicke encephalopathy.

We discuss why this issue deserves greater attention, the symptoms that may be easy to overlook, and what the growing use of GLP-1 therapies could mean for nutritional monitoring and clinical research.

As GLP-1 medications reshape weight management, should we also be thinking more carefully about what patients may be losing beyond weight?