IBS isn’t simply a digestive disorder—it’s increasingly understood as a complex disorder of gut-brain interaction.

An 8-week randomized, double-blind, placebo-controlled trial investigated whether a multi-species probiotic could influence not only IBS-related quality of life, but also oxidative stress and inflammatory biomarkers.

In Episode 141 of the Orange Pill Podcast, we unpack four surprising findings from the study—from improvements in quality of life to the unexpected disconnect between symptom improvement and systemic inflammatory markers—and explore what they reveal about the increasingly complex relationship between the microbiome, gut and brain.