Can the same supplement produce completely opposite biological effects depending on sex?

A 2026 preclinical study investigating calcium alpha-ketoglutarate (Ca-αKG) in mouse models of lung adenocarcinoma found a striking divergence: supplementation reduced tumor growth and cell proliferation in female mice, while increasing both in males. Pasted markdown

In Episode 143 of the Orange Pill Podcast, we explore how researchers traced this unexpected response to epigenetic reprogramming, why genes including Kdm6a, TBX5 and TP53 may help determine the outcome, and what this research could mean for a future where nutrition becomes increasingly sex-aware and genetically informed.