When it comes to supplements, we often assume that a higher dose means a bigger effect. A 2025 randomized, double-blind crossover trial of Rhodiola rosea challenges that assumption.

After just seven days, 200 mg/day outperformed a 1,500 mg/day dose across several resistance-training outcomes, including repetition volume and upper-body strength, while neither dose meaningfully improved 30-second cycling sprint performance. Pasted markdown Pasted markdown

In Episode 145 of the Orange Pill Podcast, we unpack the surprising dose-response relationship, why the benefits appeared specific to certain types of performance, and what the findings reveal about one of supplement science’s most important lessons:

More isn’t always better.