Episode 32: Efficacy of Probiotic Supplementation for Constipation and Well-being in Older Adults

In this episode, we explore the findings of a newly published clinical trial investigating the impact of an 84-day probiotic regimen on gut and mental health in older adults aged 50–85 who experience occasional constipation. The probiotic blend—Lactiplantibacillus plantarum strains KABP031 and KABP032 (marketed as INNERIM™)—was tested in a randomized, double-blind, placebo-controlled study to evaluate its efficacy and safety.

The results are significant:
– Participants taking the probiotic showed increased bowel movement frequency and improved stool consistency as early as Day 42.
– By Day 84, they also reported a significant reduction in perceived stress, highlighting a promising link between gut health and emotional well-being.
– The probiotic was well-tolerated, with no major side effects, supporting its use as a safe, non-pharmacological option for improving quality of life in older adults.

Join us as we unpack the study’s methodology, key outcomes, and what this means for the future of digestive health, aging, and microbiome-focused interventions. Whether you’re a clinician, researcher, or just curious about how the gut-brain connection works, this episode offers meaningful insights.