Neuropathic pain affects up to 18% of the global population and remains one of the most difficult chronic conditions to manage. Existing therapies often come with serious trade-offs such as sedation, dependency, and limited long-term relief, highlighting the urgent need for safer, more effective solutions.

In Episode 80 of the Orange Pill Podcast, we explore fascinating new preclinical research on geraniin, a naturally occurring compound found in plants like the peel of the rambutan fruit. The study suggests this compound doesn’t just blunt pain signals, it may actually help damaged nerves function better.

Rather than acting as a single-target “painkiller,” geraniin demonstrated a multi-pathway approach, addressing several biological drivers of nerve damage at once.

This research highlights the growing potential of complex natural compounds in tackling equally complex chronic conditions.