In this randomized, double-blind, placebo-controlled, multicentre, parallel, 8-week study, the efcacy of a daily dose of 1200 mg of protein hydrolysate from Coldwater Shrimp (Pandalus borealis) on ambulatory and ofce blood pressure was investigated in 144 free-living adults with mild to moderate hypertension. Te primary outcomes of the study were daytime ambulatory systolic blood pressure and ofce blood pressure. During the 8-week intervention period and in the intention-to-treat analysis (n=144), there were signifcant reductions in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group in daytime ambulatory systolic blood pressure at 4 weeks (p=0.014) and at 8 weeks (p=0.002), and in ofce systolic blood pressure at 2 weeks (p=0.031) and 4 weeks (p=0.010), with a trend toward signifcance at 8 weeks (p=0.087). By 8 weeks, signifcant and favourable improvements in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group were also observed for several secondary outcomes, including 24-hour ambulatory systolic and diastolic blood pressure, daytime ambulatory diastolic blood pressure, and daytime and 24-hour ambulatory mean arterial pressure. Also by Week 8, there was a statistically signifcant diference between groups in the distribution of subjects across National Institutes of Health-defned blood pressure categories (i.e., Normotensive, Prehypertensive, Stage 1 hypertension, and Stage 2 hypertension), with a more favourable distribution in the shrimp-derived protein hydrolysate group than in the placebo group (p=0.006). Based on exploratory analyses conducted only in participants in the shrimp-derived protein hydrolysate group, angiotensin II levels were signifcantly reduced relative to baseline.
Shrimp-protein-hydrosylate-and-blood-presure-Musa-Velosa-2019