Abstract
Background
An open-label, exploratory study has been conducted to investigate the efficacy of BDNF Essentials® for cognitive function and neurological health.
Methods
Twenty healthy adults ≥45 years of age, with a score ≥24 on the Mini-Mental State Examination (MMSE-2) and self-reported memory complaints were supplemented with BDNF Essentials® for 84 days. Computerized Mental Performance Assessment System (COMPASS) tests for memory, attention, and processing speed were conducted, and change in plasma brain-derived neurotrophic factor (BDNF), Profile of Mood States (POMS), the Healthy People Sleep Quality Index (HPSQI), perceived stress scale (PSS), and salivary cortisol, interleukin (IL)-6, and tumour necrosis factor α (TNF α) were assessed at baseline and days 28, 56, and 84.
Results
Supplementation with BDNF Essentials significantly increased COMPASS tests for memory, attention, and processing speed (all p < 0.05). Salivary cortisol was found to be significantly decreased at days 56 and 84 (p < 0.05), and IL-6 decreased at day 84 (P > 0.05). A reduction in depression-dejection at day 56 and in confusion bewilderment at day 84, and an improvement in sleep satisfaction at day 56 (all p < 0.05) were reported.
Conclusion
BDNF Essentials improved reaction time in measures of working memory, episodic memory, and attention, reduced biomarkers of stress and inflammation, and improved mood and sleep. BDNF Essentials has been found to be safe and well-tolerated in adults with self-reported memory complaints