The KGK Augmented RCT© – Moving the Gold Standard to the Supplement Industry

The randomized controlled trial (RCT) has long been considered the gold standard in clinical research—but is it always the best fit for the complex, multi-targeted nature of dietary supplements? This thought-provoking white paper from KGK Science explores the limitations of traditional RCTs in the context of nutrition science and proposes an innovative solution: the KGK Augmented RCT©. By integrating methodologies such as N-of-1 trials, open-label phases, global health indices, and broader inclusion criteria, the Augmented RCT© offers a more flexible and holistic framework tailored for the supplement industry. Learn how this adaptive design can enhance claim substantiation, reduce trial failure, and align more closely with real-world consumer outcomes—while maintaining scientific rigor and regulatory compliance. Ideal for sponsors, product developers, and regulatory strategists, this white paper redefines how evidence can be generated for functional foods and nutraceuticals in a personalized health landscape.