The Orange Pill Podcast

What if many of the ingredients in your food were never reviewed by the FDA? In Episode 88 of the Orange Pill Podcast, we break down the newly introduced GRAS Oversight and Transparency Act (February 3, 2026); a bill that aims to close one of the most controversial loopholes in U.S. food regulation. For decades, the “Generally Recognized as Safe” (GRAS) framework has allowed companies to self-determine ingredient safety without...

Erythritol has earned a near-perfect reputation in the clean-eating world. It’s natural, calorie-free, keto-friendly, and widely considered one of the safest sugar substitutes on the market. But new research from the University of Colorado suggests that this confidence may be dangerously misplaced. In Episode 87 of the Orange Pill Podcast, we unpack a startling new study from the DeSouza laboratory that shows how erythritol may quietly compromise the blood-brain barrier...

Many wellness and nutraceutical companies believe that calling a product a dietary supplement creates a regulatory safe zone. FDA enforcement actions tell a very different story. In Episode 86 of the Orange Pill Podcast, we break down the FDA’s Bioresearch Monitoring (BIMO) Program and analyze recent FDA Warning Letters that caught sponsors, CROs, and IRBs completely off guard. This episode explains a hard regulatory truth: the FDA does not regulate...

For years, protein dominated the wellness conversation. Shakes, bars, and macro tracking became the gold standard of “healthy.” But a new movement is rapidly reshaping nutrition culture and it isn’t coming from gyms or supplement brands. It’s coming from the gut. In Episode 85 of the Orange Pill Podcast, we unpack the science behind #Fibermaxxing - the viral trend shifting attention from protein obsession to microbiome-driven health. This episode explores...

For decades, America’s food system operated in a gray zone where chemicals could quietly enter the supply chain, nutrition guidance lagged behind chronic disease, and safety was often reactive rather than preventive. That era is ending. In Episode 84 of the Orange Pill Podcast, we unpack the FDA’s newly solidified Human Foods Program (HFP) and its sweeping 2026 agenda, a regulatory blueprint that signals one of the most aggressive transformations...