The Orange Pill Podcast

What if supporting healthy aging isn't just about producing more NAD+, but also understanding why our cells lose it in the first place? In Episode 150 of *The Orange Pill Podcast*, we explore the science behind NAD+, a molecule essential for cellular energy and DNA repair, and CD38, an enzyme increasingly studied for its role in age-related NAD+ decline. We take a closer look at DailyColors®, a Mediterranean-inspired blend of...

The FDA has finalized its guidance on identity and safety information for New Dietary Ingredient Notifications (NDINs). But what does this mean for the dietary supplement industry? In Episode 149 of The Orange Pill Podcast, we break down the finalized guidance, exploring the FDA's recommendations for establishing ingredient identity, presenting safety evidence, and supporting safety conclusions. With KGK Science's regulatory expertise extending to Dr. Corey Hilmas, our Chief Regulatory Officer,...

What if slowing biological aging didn't require expensive treatments or extreme lifestyle changes? In Episode 148 of The Orange Pill Podcast, we explore findings from the landmark DO-HEALTH Bio-Age trial, which followed 777 adults aged 70 and older over three years to investigate whether omega-3 fatty acids, vitamin D, and simple home exercise could influence biological aging. Using advanced epigenetic clocks, researchers found that omega-3 supplementation modestly slowed several measures...

Creatine is best known for building muscle and boosting athletic performance, but could its benefits extend beyond the gym? In this episode of The Orange Pill Podcast, we explore a 2025 study published in Nutrients examining creatine's effects on sleep, cognitive function, physical performance, and muscle recovery. After just seven days of supplementation, participants reported better sleep quality, demonstrated improved attention, and achieved greater high-intensity exercise performance. But with some...

What if your muscles could regain strength before the soreness disappears? Emerging research suggests that plant-derived polyphenols may influence exercise recovery in ways that go beyond simply reducing discomfort. Recent studies investigating Sorghum bicolor and specialized fruit polyphenol extracts have reported promising findings involving muscle strength recovery, exercise-related biomarkers and cellular signaling pathways associated with muscle growth. In Episode 146 of the Orange Pill Podcast, we explore the science behind...