The Orange Pill Podcast

A proposed FDA rule could fundamentally change how new food ingredients enter the U.S. marketplace. In Episode 133 of the Orange Pill Podcast, we unpack the FDA's proposal to move from voluntary to mandatory GRAS notifications, and explore what this shift could mean for food innovation, regulatory transparency, consumer safety, and the future of ingredient development....

Millions of people struggle with constipation, yet many still rely on laxatives that simply force the digestive system into action. In Episode 132 of the Orange Pill Podcast, we explore why fructooligosaccharides (FOS)—a clinically studied prebiotic—may represent a smarter approach to digestive health. Learn how FOS nourishes beneficial gut bacteria, promotes natural bowel function, and supports long-term digestive wellness through the power of the microbiome....

Clinical trials are essential, but choosing the wrong dose, population, or endpoint can derail a study before it begins. In Episode 131 of the Orange Pill Podcast, we introduce the KGK Design Intelligence Lab and explore how in silico dietary modeling can simulate health outcomes across virtual populations before the first participant is enrolled. By combining randomized clinical trial data, NHANES population insights, and advanced statistical modeling, researchers can design...

Can one of the world's most researched plant compounds actually improve athletic performance, or have we been asking the wrong question? In this episode of the Orange Pill Podcast, we explore the science behind quercetin, the flavonoid once hailed as an "exercise mimetic" after remarkable animal studies. Discover why early human trials largely disappointed, how new delivery technologies are changing the conversation, and why quercetin's greatest benefit may not be...

For decades, America's food innovation system has relied on the self-GRAS pathway, allowing companies to determine the safety of new ingredients without mandatory FDA notification. That system may be about to change. In this episode of the Orange Pill Podcast, we explore the proposed federal legislation that could fundamentally reshape how food ingredients reach the marketplace, and what it means for manufacturers, regulators, and consumers alike....