The Orange Pill Podcast

Dietary supplements are no longer a niche wellness habit. According to a new 2026 report from the National Center for Health Statistics, 60.2% of U.S. adults used at least one dietary supplement in the previous 30 days—and 38.7% used two or more. In Episode 142 of the Orange Pill Podcast, we unpack the latest NHANES data to explore who's supplementing, how habits change with age and sex, and the rise...

IBS isn't simply a digestive disorder—it's increasingly understood as a complex disorder of gut-brain interaction. An 8-week randomized, double-blind, placebo-controlled trial investigated whether a multi-species probiotic could influence not only IBS-related quality of life, but also oxidative stress and inflammatory biomarkers. In Episode 141 of the Orange Pill Podcast, we unpack four surprising findings from the study—from improvements in quality of life to the unexpected disconnect between symptom improvement and...

GLP-1 receptor agonists have transformed the conversation around obesity and metabolic health. But as their use continues to grow, researchers and clinicians are beginning to pay closer attention to the nutritional consequences that can accompany significant appetite suppression, rapid weight loss, and persistent gastrointestinal side effects. In this episode of The Orange Pill Podcast, we explore the emerging concern around thiamine (vitamin B1) deficiency in people using GLP-1 receptor agonists....

Fiber isn't just about digestive health. A systematic review and meta-analysis of 27 randomized controlled trials involving more than 1,400 participants found that soluble fiber supplementation was associated with improvements in body weight, BMI, waist circumference and markers of insulin resistance. In Episode 139 of the Orange Pill Podcast, we explore why 12 weeks matters, how soluble fiber interacts with the gut microbiome and satiety pathways, and why this simple...

Creatine may be famous for building muscle, but its next frontier could be the brain. A 2024 systematic review and meta-analysis of 16 randomized controlled trials found that creatine supplementation was associated with improvements in memory, with additional promising findings around attention and processing speed. In Episode 138 of the Orange Pill Podcast, we explore how creatine helps fuel the brain's enormous energy demands, why women and younger adults showed...