Weight Loss and Maintenance – Putting Weight into Weight Loss Claims

With rising global obesity rates and growing consumer interest in effective weight management solutions, the demand for scientifically substantiated weight loss products has never been greater. This white paper critically examines the complexity of weight loss, highlighting the limitations of popular claims and the need for rigorous clinical evidence. It explores the roles of genetics, gut microbiota, hormones, and molecular biology in body weight regulation and introduces the concept of a Global Index as a more holistic and relevant endpoint for weight loss studies. Featuring insights into regulatory scrutiny, market trends, and innovative clinical trial designs like the Augmented RCT and N-of-1 trials, this is a must-read for companies aiming to develop credible and compliant weight management products.